Head-to-tail polymerization of microtubules in vitro. Electron microscope analysis of seeded assembly.

The discrepancy seems to arise from the fact that they measured net addition or loss of subunits from polymer, whereas we have dissected the net reactions into an algebraic sum of addition and loss at each end. Our results may be significant for models of mitosis based on assembly-disassembly (10, 8) and in particular a recent model by Margolis et al.

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