Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.

The sequence conservation of these three isoforms with other ATPases further supports the idea that different ion transport ATPases derived from a common ancestral gene (Serrano et al., 1986). Significance of Na,K-ATPase a Subunit lsoform Diversity The identification of isoform diversity exhibiting tissue- specific and developmental regulation is highly significant as it could provide the basis for Na,K-ATPase functional di- versity.

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