Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

J Exp Med · 2007 · PMC2118455 · PMID 17893198

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highly significantno p-value reported

Of note, APC treatment of LPS-challenged EPCR δ/δ , but not of PAR1 −/− , mice elicited a highly significant 10- and 7-fold augmentation of IL-6 and monocyte chemoattractant protein 1 levels, respectively (Table S3).

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