highly significantP < 0.001
The reduction in CSR is highly significant for all three genotypes (P < 0.001).
The reduction in CSR is highly significant for all three genotypes (P < 0.001).
Breaks in ape2 Y/− B cells, however, do not display a G:C bp preference and occur at AID hotspots only with borderline significance (P = 0.047; Table I ).