Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.

J Exp Med · 2007 · PMC2118701 · PMID 17724130

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highly significantno p-value reported

Here, we demonstrate that in the chronic phase of progressive SIV infection, effector site CD4 + T EM cell populations manifest a slow, continuous decline, and that the degree of this depletion remains a highly significant correlate of late-onset AIDS.

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