Mediation of chemoattractant-induced changes in [Ca2+]i and cell shape, polarity, and locomotion by InsP3, DAG, and protein kinase C in newt eosinophils.

J Cell Biol · 1994 · PMC2120201 · PMID 7929591

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highly significantno p-value reported

The suppression of the initial Ca2+ spike by 1,2-DOG is highly significant and leads to the same conclusion as the effects of PKC inhibitors, that a chemoat- tractant-induced increase in DAG and PKC activity causes flattening and lamellipod extension and limits the magnitude of the initial Ca2/ spike.

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