The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae.

For various numbers of 0.2 txm circles representing two classes of signals, randomly distributed on a 2-txm surface, the frequency of overlap varies between 2.6% and 5.8% (as indicated in Table I). This indicates that the frequencies of colocalization ob- served for Rapl and Sir foci with Y' signals (54-74%) are highly significant, while the value observed for L YS2 and Rap1 (9%) would be consistent with chance coincidence.

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