Critical relationships between constituents of the antigen-adjuvant emulsion affecting experimental allergic encephalomyelitis in a completely susceptible mouse genotype.

Since the publication of the Kies and Alvord book "Allergic Encephalomyelitis" (1), there has been an increasing trend toward the use of "experimental allergic encephalomyelitis," or EAE, as a rubric for the phenomenon. 157 158 ANTIGEN-ADJUVANT COMPOSITIONIN EAE the instance of the mouse and we have used the histopathologic diagnosis solely, since it has the merit of providing a datum which is indeed the decisive one for render- ing a verdict of whether or not the disease has been produced.

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