Induction of apoptosis by PBMCs cultured without IFN-α for 24 h was less reliably elicited (showing a mean 15% increase over background levels in patients with liver disease [P = 0.04] and a nonsignificant trend to increased levels in this group compared with controls; Fig. 7 c ).
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Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage.
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