QUANTITATIVE STUDIES ON THE BEHAVIOR OF SENSITIZED LYMPHOCYTES IN VITRO : I. RELATIONSHIP OF THE DEGREE OF DESTRUCTION OF HOMOLOGOUS TARGET CELLS TO THE NUMBER OF LYMPHOCYTES AND TO THE TIME OF CONTACT IN CULTURE AND CONSIDERATION OF THE EFFECTS OF ISOIMMUNE SERUM.

(~sz) targetcellssurvivingafter incubationwithnormalL.N.ceils Normal serum (X l0s) 271 4- 13.7 201 4- 8.9 254 4- 11.6 530 -4- 29.3 692 4- 23.2 550 4- 40.0 924 4- 18.4 872 4- 35.6 Immuneserum(X IOS) 310 4- 13.7 207 15.3 304 -4- 18.8 466 -4- 24.9 691 4- 17.6 449 -4- 35.2 700 28.0* 796 --r-24.4 * Difference in means is highly significant (0.01 > P). the concentration of immune serum in the culture media on the destructive capabilities of sensitized lymph node cells.

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