The photodynamic response of two rodent tumour models to four zinc (II)-substituted phthalocyanines.

Viable tumour cells were present on one side of the capsule while on the inner edge there was a band of karyhorrexic cells, followed by a band of pyknotic cells and debris of 20 gm mean width that surrounded a central core of pyknotic and karyhorrexic cells, interspersed with collagen fibres and large spaces. There was a highly significant difference (P < 0.01) in the mean vascularity of the two untreated tumour models, with vascular components six times higher in the LSBDI tumour (10.8% ? 1.5) than in the LMCI tumour (1.8% ? 1.4).

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