Barely Significant
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Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells.

J Exp Med · 2007 · PMC2150985 · PMID 18056287

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hedged sentence
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closest p · 0.0× alpha
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boldest claim

The sentences

highly significantP < 10 −54actually significant
The highly significant (P < 10 −54 ) preference for TGT codons at Cys 104 , but not Cys 23 , suggests selection for site V recombinogenic sequence that is independent of the amino acids necessary for BCR structure.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.