Mechanism of the inhibition of Ca2+-activated Cl- currents by phosphorylation in pulmonary arterial smooth muscle cells.

In comparison to ATP, I ClCa in cells dialyzed with AMP-PNP deactivated more slowly (the difference at 250 nM Ca 2+ was just at the limit of significance with P = 0.080), an effect that was accentuated at higher [Ca 2+ ] i (note that for [Ca 2+ ] i > 500 nM, the slow time constant of deactivation in AMP-PNP was compared with the single τ deact measured with ATP; see online supplemental material for further details).

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