Splice variation in the cytoplasmic domains of myelin oligodendrocyte glycoprotein affects its cellular localisation and transport.

J Neurochem · 2007 · PMC2156149 · PMID 17573820

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Despite constituting only ∼0.05% of the total myelin protein ( Johns and Bernard 1999 ), MOG is a highly significant B cell autoantigen in MS, with antibodies against MOG contributing to myelin destruction ( Schluesener et al. 1987 ; Linington et al. 1988 ; Litzenburger et al. 1998 ; Storch et al. 1998 ).

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