Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.

An analysis of covariance revealed a highly significant relationship between macroautophagy suppression by amino acid supplementation and reduction in Aβ levels (Aβ40, P < 0.01; Aβ42, P < 0.001) and between macroautophagy induction by Leu/His deprivation and increased Aβ production (Aβ40, P < 0.01; Aβ42, P < 0.0001).

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5 B), although there was a nonsignificant trend toward greater effects on Aβ42 production, as indicated by an increase in the ratio of Aβ42 to Aβ40.

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