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IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes.

J Cell Biol · 2004 · PMC2171962 · PMID 14709544

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a decreasing trendno p-value reported
In cultures treated with IGF-I, the percentage of RIP − cells that incorporated BrdU also exhibited a decreasing trend in the first three time periods, but to a lesser extent compared with the cells grown without IGF-I ( Fig. 3 B, blue columns).

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