H2AX regulates meiotic telomere clustering.

However, we noted a 20-fold increase in the frequency of H2AX −/− bouquet-stage nuclei ( H2AX −/− , 6%; wild-type, 0.4%; based on 2,567 mutant and 2,772 wild-type spermatogenic nuclei), with the differences being highly significant (P < 0.0001; χ 2 and Fisher test; Fig. 2 B).

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