Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia.

There was a highly significant difference between clinical categories in the percentage of var genes amplified that were DBLα1-like. 80.1% of the var gene sequences amplified from the cerebral malaria isolates were DBLα1-like, compared to only 25.7% of the sequences from the hyperparasitaemia isolates and 40.5% of the sequences from the uncomplicated malaria patients ( P < 0.001, Chi-square test, Fig. 1 ).

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