It may be significant that the failure of allograft memory cells to recirculate is probably compensated in vivo by their widespread distribution and greatly enhanced potency so that blood to lymph recirculation is not in fact required to guarantee that sufficient antigen sensitive cells will he available at a local lymphoid site of alloantigen deposition.
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The cellular basis of allograft rejection in vivo. II. The nature of memory cells mediating second set heart graft rejection.
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