Human platelet activation by C3a and C3a des-arg.

J Exp Med · 1983 · PMC2187348 · PMID 6604123

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highly significantno p-value reported

However, at lower concentrations (2 X 10(-12) M) C3a did not aggregate platelets directly but exhibited highly significant synergism (two-way analysis of variance P less than 0.0001) with ADP in mediating platelet aggregation and release of serotonin.

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