Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology.

J Exp Med · 1994 · PMC2191492 · PMID 7909326

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highly significantno p-value reported

2, a modest but highly significant increase in IL-12 p40 mRNA was detected after injection of eggs, reaching a maximum by day 3 and returning to baseline levels by day 14.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.