Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.

Although both Gad structural genes map to Chr 2 (16), they are positioned proximal to I11 in areas in which all markers typed to date havebeen NOD derived. Thus, NOD and NOR mice must be presumed to share the same Gad genes. Other PotentialRegions ConferringWeak Resistancein NOR. Presence of a weaker (and recessive or poorly penetrant) resistance gene on the more distal segment of Chr 4 was suggested by a marginally significant segregation distortion associated with the D4MitI1 and the naturiuretic peptide precursor A (Nppa, formerlyPnd) markers.

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NOD and NOR progenitors were homozygous for all alleles typed. Highly significant linkage with IDDM resistance was as- sociated with homozygosity for NOR alleles on Chr 2.

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