Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.

Whereas there was no statistically significant difference in disease scores between iNOS KO and wild-type mice that did not receive IL-12 ( P = 0.74), scores of IL-12–treated iNOS KO and IL-12–treated wild-type mice differed at the highly significant probability value of P < 0.005.

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