The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity.

Although there was no difference between the three BCR/ABL oncogenes in induction of a CML-like disease in recipients of transduced marrow from 5-FU–treated donors, there was a highly significant difference in survival of recipients of P190-transduced marrow compared with recipients of P210- and P230-transduced marrow when donors were not pretreated with 5-FU.

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