Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs.

J Exp Med · 1999 · PMC2193074 · PMID 10359586

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may be significantno p-value reported

In contrast, there may be significant selection pressure between clones in vivo, as Ag depots recede over the course of the response.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.