These findings, together with the above results, emphasize the Eβ function on the chromosomal structure of the Dβ-Jβ regions and bring support to the hypothesis that recruitment of a histone acetyltransferase (HAT)-containing complex and changes in histone acetylation may be significant features of Eβ-mediated activation of TCR-β locus expression and recombination.
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Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination.
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