Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

J Exp Med · 2002 · PMC2193701 · PMID 11994416

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likely to be significantno p-value reported

This is likely to be significant for the activation of the lipase as mutations in SLP-76 which block its ability to bind PLCγ1 lead to reduced TCR-induced PLCγ1 phosphorylation ( 42 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.