Highly significant, but less dramatic differences in baseline ear thickness also developed spontaneously in FVB.δ −/− mice relative to age-matched FVB controls ( Fig. 1 E); this was paralleled by qualitatively similar, albeit less intense, histologic differences as described for NOD.δ −/− mice (data not shown).
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Resident skin-specific gammadelta T cells provide local, nonredundant regulation of cutaneous inflammation.
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