Barely Significant
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Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10.

J Exp Med · 2003 · PMC2193816 · PMID 12538658

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highly significantno p-value reported
These observations are highly significant, as only very few percent of CD4 + T cells in an immune system at steady state express ICOS.

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