Exploiting the redundancy in the immune system: vaccines can mediate protection by eliciting 'unnatural' immunity.

J Exp Med · 2003 · PMC2193913 · PMID 12782708

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highly significantno p-value reported

( 8 ) that CD8 + T lymphocytes can mediate long lasting protection against fungi in the absence of CD4 + T lymphocytes is highly significant, with important implications for vaccination of immunocompromised hosts.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.