Frame disruptions in human mRNA transcripts, and their relationship with splicing and protein structures.

BMC Genomics · 2007 · PMC2194788 · PMID 17937804

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highly significantno p-value reported

We find significant avoidance of protein-domain disruption (indicating a selection pressure for this), and highly significant overrepresentation of disruptions in alternatively-spliced exons, and 'non-NMD' regions.

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