Barely Significant
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The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.

J Exp Med · 1997 · PMC2196128 · PMID 9016873

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The sentences

highly significantP <10 −4actually significant
Chi-squared comparison of the frequency of mutations in the V genes expressed by hybridomas derived from BP2 transgenic mice revealed the frequency difference between endogenous canonical V H genes and B29 promoter-driven 36-65V H genes present in hybrid loci was highly significant ( P <10 −4 ).

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