The inhibition of virus binding paralleled that of neutralization with increasing sCD4 concentration, suggesting a relationship: an excellent and highly significant correlation was demonstrated after analysis of the results, and is summarized in Table 1 ( r = 0.96 and 0.93 for Hx10 and MN, respectively).
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Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralization.
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