Testing for an association between ovarian carcinoma subtype and kisspeptin status, there was a highly significant positive association with clear cell carcinoma, and a significant negative association with serous carcinoma subtype (χ 2 , p < 0.0001).
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Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma.
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When disease specific survival and overall survival were analyzed within each ovarian carcinoma subtype, the log-rank test for kisspeptin-IR status failed to achieve significance (due to insufficient sample size), although for the clear cell cases statistical significance was approached (p = 0.1042, p = 0.0859, results not shown).