An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model.

Transchromosomic tumours showed an approximately three-fold lower mean percentage of neuroectodermal tissue, both when compared across all tumours (highly significant by two tailed t-test (p = 0.004), and when compared strictly within pairs of tumours which grew in the same animal (n = 16 pairs, paired t-test, p = 0.037), (Fig. 1B ).

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