Lack of evidence for changing virulence of HIV-1 in North America.

PLoS One · 2008 · PMC2211407 · PMID 18253479

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a decreasing trendno p-value reported

an increasing trendno p-value reported

[4] , analyzed Australian, Canadian, and European cohorts from 1985 to 2002, and found a decreasing trend in the first CD4 cell count (n = 3687) and an increasing trend in the first viral load (n = 1584) after seroconversion.

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