Comparison of estimation capabilities of response surface methodology (RSM) with artificial neural network (ANN) in lipase-catalyzed synthesis of palm-based wax ester.

With very small P -value (0.0001) from the analysis of ANOVA and a suitable coefficient of determination (R 2 = 0.995), the quadratic polynomial model was highly significant and sufficient to represent the actual relationship between the response (percentage yield) and the significant variables (Table 2 ).

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