Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding.

Mol Neurodegener · 2007 · PMC2211485 · PMID 18067682

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a nonsignificant trendno p-value reported

We found no consistent effect of Eve-1c or Eve-1d on either basal or phorbol-stimulated sAPPα secretion (Figure 5 ), although, in some experiments, Eve-1c showed a nonsignificant trend toward potentiation of shedding.

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