CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract.

J Exp Med · 2004 · PMC2211962 · PMID 15365096

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highly significantno p-value reported

This is underscored by the highly significant correlation between collagen deposition, CD4 + T cell depletion ( 28 ), and CD4 + T cell repletion (unpublished data) on antiretroviral therapy.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.