An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease.

J Exp Med · 1998 · PMC2212155 · PMID 9463404

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highly significantno p-value reported

The production of IL-10 by the CD4 + T cells is highly significant biologically as coinjection of anti–IL-10 largely reversed the autoimmune suppressive effects of anti–IL-12.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.