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Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction.

J Exp Med · 2005 · PMC2213327 · PMID 16314434

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might be significantno p-value reported
PD-1 acts as an important negative regulator of T cell responses ( 31 ), and it might be significant that this molecule is induced after in vivo treatment with 1018 ISS on TLR-9 + PDCs in the airways.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.