PD-1 acts as an important negative regulator of T cell responses ( 31 ), and it might be significant that this molecule is induced after in vivo treatment with 1018 ISS on TLR-9 + PDCs in the airways.
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Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction.
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