Because a positive trend between (reporter) alignment strength and expression correlation is not unexpected for functionally related genes like paralogous genes or genes that share protein domains, we defined a filtering criterion to set aside gene pairs that aligned to each other with BLAST [ 37 ] in at least one direction with an E-value smaller than 10 -10 (see Methods).
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In situ analysis of cross-hybridisation on microarrays and the inference of expression correlation.
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