Kaplan–Meier probability curves for recurrence-free survival indicated that younger age and PR-negative status were associated with earlier relapse, but these outcome differences did not quite reach statistical significance (age, P = 0.09; PR status, P = 0.08; log-rank analyses).
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Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers.
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Luminal markers, commonly used as an expression array signature for ER-positive breast cancers, showed no significant relationship with age cohort, ERBB2 status or PR status, although there was a nonsignificant trend for luminal gene expression to associate with PR-positive cases.