Metabolic studies of human primitive neuroectodermal tumour cells by proton nuclear magnetic resonance spectroscopy.

There is a possibility that the expression of NAA by medulloblastomas reflects, in fact, their origin from a progenitor cell with the phenotypic characteristics of an 0-2A progenitor cell, rather than of a neuronal progenitor. Nonetheless, the highly significant differences in NAA levels between cerebellar medulloblastomas and PNETs from other CNS locations may suggest differences in lineage origin for these tumours, as well as differences from other tumours of the CNS, which have been studied by Florian et al (1995, 1996).

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