Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumour front of oral squamous cell carcinomas.

Several attempts have been made to improve the prognostic accuracy as well as to minimize the subjectivity of established classifications. Received 15 August 1996 Revised 13 November 1996 Accepted 19 November 1996 Correspondence to: KW Schmid Most recently, malignancy grading of the deep invasive margins of oral and laryngeal squamous cell carcinomas proved to yield highly significant and independent prognostic information (Bryne et al, 1992, 1995; Welkoborsky et al, 1995; Woolgar and Scott, 1995).

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The 'classical' prog- nostic parameters, pT and pN stage, of the tumours showed statis- tically significant correlation with overall survival only in univariate analysis, whereas Broders grading and age of the patients did not achieve significance.

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