In one study, Manoharan and Banerjee (1985) reported that in the mammary epithelial cell trans- formation model in organ culture, the presence of BC during 24 h treatment (initiation stage) of the glands with the carcinogens, e.g. DEN, dimethylbenz(a)anthracene and methyl nitrosourea, caused a highly significant reduction of SCE induced by the same carcinogens.
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Beta-carotene inhibits rat liver chromosomal aberrations and DNA chain break after a single injection of diethylnitrosamine.
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