The relationship between intrinsic thymidylate synthase expression and sensitivity to THYMITAQ in human leukaemia and colorectal carcinoma cell lines.

TS protein could not be detected in the HL60 cell line, possibly as a result of excessive protein degradation (as indicated by the lack of protein bands on Coomassie blue-stained gels; data not shown). Linear regression analysis of the rhTS standard curve on each gel always gave a highly significant positive correlation, with r2 values above 0.94 in each of the nine gels analysed (mean ? standard devi- ation of 0.97 ? 0.02).

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