The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer.

Int J Clin Pract · 2007 · PMC2228389 · PMID 17892469

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highly significantno p-value reported

In the BIG 1–98 trial, 2.5% of women randomised to letrozole had serious or fatal cardiac events compared with 1.1% taking tamoxifen; this was highly significant ( 27 ).

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