For example, a search with the sequence from Hyperthermus butylicus (Hbut_0467) used as the query retrieved the Rpb8 sequence from fission yeast Schizosaccharomyces pombe in the 2 nd iteration, with a E-value of 0.004, and numerous eukaryotic Rpb8 sequences in the 3 rd iteration, with highly significant E-values.
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Orthologs of the small RPB8 subunit of the eukaryotic RNA polymerases are conserved in hyperthermophilic Crenarchaeota and "Korarchaeota".
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