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Mucopolysaccharidosis type II (Hunter syndrome): a clinical review and recommendations for treatment in the era of enzyme replacement therapy.

Eur J Pediatr · 2008 · PMC2234442 · PMID 18038146

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may be significantno p-value reported
The burden of weekly intravenous therapy may be significant in some patients with very severe CNS disease.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.